Assay Scientist
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Job Detail
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Offered Salary 0
Job Description
Accountabilities:
You will take part in developing high-quality biochemical and cell-based high throughput functional assays for drug discovery and technology development programs. Specifically, characterize multi-specific antibodies and other complex biologics in monolayer and 3D model systems, such as spheroids and organoids. You will contribute to the development of novel drug discovery screening platforms.
- Work closely with a Senior Scientist to establish HTP (96/384 well) assay platforms for screening biologics modalities.
- Develop assays using cell lines and primary immune cells.
- Help design and execute 3D assays for functional screening of T-cell engagers, ADCs, and cytokine-fusions among other complex modalities.
- Support the development of live-cell high content, high throughput imaging assays for the characterization of novel biologics and for the mechanistic understanding of complex drug-target interactions.
- Apply confocal imaging, ELISA, and flow-based methods for profiling and characterization of the cellular response to treatment.
- Identify creative solutions to sophisticated assay, technology, or drug discovery project problems.
Essential Skills/Experience:
- Masters degree in Cell Biology, Immunology, Biochemistry or similar field with at least 2 years of relevant experience in industry.
- Background in drug discovery in the pharmaceutical industry.
- Experience and in-depth technical knowledge of high throughput assay development, screening in 384-wells plate format, with a dedication to quality and scientific rigor.
- Experience handling primary cells and cell lines, including PBMC isolation.
- Strong teammate with good communication skills and experience of working in multi-disciplinary teams.
- Ability to tackle challenges creatively and contribute and improve assay technologies and processes.
Desirable Skills/Experience:
- Knowledge of biologics drug discovery and in vitro pharmacology.
- Experience with 3D cell culture and live high-content imaging or confocal microscopy.
- Familiarity with relevant software for image data analysis, such as ImageJ, Imaris.
- Project leadership experience.
- Experience of working within matrix teams.
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Application ends in 16d 6h 12min