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@ MacroGenics
  • Post Date : Apr 3, 2025
  • Apply Before : May 3, 2025
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Job Detail

  • Offered Salary 0
  • Commitment Full Time
  • Compensation Paid
  • Required education level Bachelor’s degreeMaster’s degree

Job Description

Summary of Position

This position is part of the Protein Science group within the Research department. The Scientist I/II will be responsible for the analysis of biomolecular interactions using Surface Plasmon Resonance (SPR) and Biolayer Interferometry (BLI) to analyze biomolecular interactions, primarily focusing on antibody-antigen binding kinetics in support of the biologics research pipeline. Additional roles include the purification of recombinant proteins and their characterization by HPLC and capillary electrophoresis.

Responsibilities and Job Duties

  • Design, execute, and analyze SPR and BLI experiments to determine antibody affinities, kinetics, and epitopes.
  • Maintain SPR and BLI instruments
  • Purify proteins and perform routine analytical characterization
  • Confirm protein identity by Liquid Chromatography-Mass Spectrometry (LC-MS)
  • Conduct protein stability tests for lead molecule selection
  • Maintain timely and accurate records

Minimum Qualifications

Scientist I

Education & Other Credentials

  • Bachelor’s (BS/BA) in Biochemistry or a related scientific field of study with 3+ years of bench-related experience within industry and/or academia.

OR

  • A Master’s degree in Biochemistry or a related scientific field of study with 0 years of bench-related experience within industry and/or academia.

Scientist II

Education & Other Credentials

  • Bachelor’s (BS/BA) in Biochemistry or a related scientific field of study with 5+ years of strong bench-related experience within industry and/or academia.

OR

  • A Master’s degree in Biochemistry or a related scientific field of study with 2+ years of strong bench-related experience within industry and/or academia.

Knowledge, Skills and Abilities

  • Understanding of biophysical principles governing protein-protein interactions and binding kinetics
  • Hands-on experience with SPR and BLI instruments
  • Ability to handle multiple tasks and willing to collaborate with other teams
  • Excellent written and verbal communications skills
  • Maintain timely and accurate records 

Preferred Knowledge and Skills

  • Knowledge and experience about protein purification
  • Hand-on experience with AKTA chromatography system preferred
  • Hand-on experience with HPLC or LC-MS preferred
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